Computer-Guided Therapy nanoparticles destroy tumors

Gold nanoshells are among the most promising new nano-therapies developed to kill tumors, such as antennas, the light energy into heat, which cooks cancer death. Well, a multi-institutional team of researchers has shown that the polymer coating gold nanorods one of their colleagues spherical, with a single dose completely destroyed tumors in a nonhuman animal model of human cancer.

Their working relationships in the journal Cancer Research, a team of researchers led by Sangeeta N. Bhatia, MD, Ph.D., Massachusetts Institute of Technology, and Michael J. Sailor, Ph.D., University of California, San Diego, describes the evolution of gold nanorods coated with polyethylene glycol, a new record for the period that remains in the bloodstream. This long half-life in circulation of approximately 17 hours, the nanorods may, within the tumors, leaky blood vessels that surround malignancies. Both Dr. Bhatia and Dr. Sailor are members of the National Cancer Institute Alliance for Nanotechnology in Cancer.

The gold nanoparticles can absorb light of different frequencies, depending on their shape. The particles stick designed to take this study near infrared light, which heats the nanorods passports but harmless by the human. In the current work, the tumors in mice that received an intravenous injection of nanorods and near infrared laser treatment have disappeared within 15 days. These mice survived for 3 months, but there is no evidence of a repetition at the end of the study, whereas in mice, treatment or who are not only the laser or nanorods death within weeks.

In a single exposure to a near infrared laser, nanorods of heat at 70 ° C, hot enough to kill tumor cells. In addition, a heating system at low temperature weakens the tumor cells to improve the effectiveness of chemotherapy treatments, which allows the use of nanorods, in addition to treatment. The nanorods also be used to kill tumor cells left after surgery. Researchers indicate that the nanorods can be more than 1000 times more precise as a surgeon's scalpel, they might remove residual cells, the surgeon may be.

Another useful feature is the gold nanorods to absorb very efficiently X-rays, increased sensitivity to x-ray CT-imaging, as the analysis. Researchers have benefited from this device, with X-rays, for a detailed map in three dimensions, where the nanorods in the tumor animals. So this map to calculate the optimal irradiation protocol, the tumor effect of death and minimize damage to healthy tissue. The nanorods "Homing capabilities as a promising tool for the diagnosis of tumors. Following the injection of particles, they can be illustrated by a technology of the Raman scattering. All tissues, the light, others like liver or spleen tissues, tumor invasive port. In a second paper, published in the journal Advanced Materials, researchers have shown, the nanorods could "imaging capabilities in the molecules that absorb in the near infrared light on the surface of the nanorods. Strengthening the basis of the surface Raman scattering, very low concentrations nanorods only a few parts per trillion in water can be detected.

Another advantage of the nanorods is that the surface of various types of light scattering of molecules, they can be designed to both collect several types of information not only about whether a tumor but, if it is a risk of invasion of other tissues, regardless of whether a tumor is primary or secondary, where he was born.

This work, in the calculation of thermal geführte photo antitumoral movement with long antennae nanorod gold ", was adopted by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative for the application of nanotechnology for the prevention, diagnosis and treatment of cancer. Investigators from the Indian Institute of Technology, Madras, also in this study. A summary is available on the website of the shirt.

This is not abstract, for the second paper "Gold nanorods SERS coded as a platform for multi-density multiplex near infrared imaging thermal heating and photo."