IVF or ICSI: Baby born from frozen embryos not as well

Amsterdam, The Netherlands: An analysis of the longest in the ICSI program in the United States had the reassuring evidence that babies born from frozen fertilized embryos in ICSI (intracytoplasmic sperm injection) may also that the birth of on frozen embryos fertilized by the treatment of in vitro fertilization. The researchers also compared babies born as a result of cycles in which women have more hormones drugs with babies born as a result of the unmedicated, natural cycles, and although it slightly higher percentage of birth defects in babies born to drug cycles, the difference was low - 2.2% against 0.4%.

Ms. Queenie Neri, a researcher at Cornell University (New York, USA) and a member of the team led by Professor Gianpiero Palermo, paving the way for ICSI in 1992, said the 25th Annual Meeting of the European Society of Human Reproduction and Embryology in Amsterdam today (Monday), she and her colleagues had the births of all frozen embryos conceived by IVF or ICSI between 1993 and 2007.

Ms. Neri identified 720 IVF and 1231 ICSI frozen embryo transfers. The survival rate of frozen embryos was 74% after IVF and 77.2% after ICSI. The clinical pregnancy was 42.8% after IVF and 39.4% after ICSI. These negotiations have resulted in 84.1% and 89.7% of IVF ICSI deliveries. 27.8% were multiple IVF pregnancies and 21.1% of ICSI pregnancies. Results at the date of birth, Apgar scores, gestational age, birth weight and malformations were both IVF and ICSI singleton baby.

When she gathers the babies, according to medical or unmedicated cycle, she found that the clinical pregnancy was 42.1% and 39.4% A, 86.7% were delivered (28.7%, with several births) and 87.5% (19.2% of births) are. Pregnancy and birth weight age were similar between the two groups, but the malformation was 2.2% of the evaluation of drugs and 0.4% of cycles in the natural cycle.

Ms. Neri said: "freezing of embryos in the context of artificial insemination is a cornerstone of the assisted reproductive technology. We found no difference in the ability of embryos by IVF or ICSI to implantation, even after the effort cryopreservation. We were not in the situation, to confirm significant power on the cycle of unmedicated newborns results of cryopreserved embryos, the price difference was small malformation.

"The initial hypothesis of the study was a difference in the outcome of newborns, whereas in the presence or absence of drugs for infertility, adoption, unmedicated cycles that are descendants better results. It is interesting, we have no clear difference in the results of new-born between medical care and unmedicated groups. From our study, the combination of exposure to cryopreservation and the drugs or not not significantly affect the results descendants. "

Abnormalities in the field of cardiac malformations in gaps, hereditary factors and sporadic genetic mutations or interactions. However, Ms. Neri said: "They were in the range of malformations in newborns in the general population."

In the absence of statistical differences between the medical and unmedicated cycles, Ms. Neri said that it was not possible to say that the cycles of drugs have been linked to higher rate of malformations, or if it was This mechanism could be responsible.

"Our study is not specific abnormalities related to the factor of male infertility, drugs or other environmental triggers such as in vitro fertilization culture, have been by other studies" she says.

"If we think about reproductive medicine has a new sub-population. These children are now on puberty, fertility and their status is not yet rated. Therefore, monitoring of children, design artificial is of paramount importance, "concluded them.