New discovery of the body control

He is known for some time that T cells attack the body's structure and, if it infiltrate the central nervous system, create diseases like multiple sclerosis (MS). T cells damage the myelin of the vagina, the material that surrounds and protects nerve cell fibers. This prejudice to slow or block messages between the brain and body, causing various symptoms of MS as movements affected.

Molecular analysis of the damaged tissue of patients with multiple sclerosis, researchers-B1 on the receiver. The data that are evaluated have shown that two pathways known to play a crucial role in the cardiovascular sector, also appear to play an important role in the central nervous system, the renin-angiotensin and kallikrein-kinins - system where the researchers in Berlin, their concentration.

The B1-receptor is part of the kallikrein-kinin system. In collaboration with Professor Alexandre Prat de l'Université de Montréal, Montreal, Canada, and Professor Lawrence Steinman of Stanford University in Stanford, California, United States, in Berlin, researchers have discovered receptor on the B1 T cells of MS patients and T-cells of mice to encephalitis, an inflammation of the brain.

The disease has worsened, as these mice do B1 on their T-cells. Therefore, with a substance (SAR-[D-Phe]-bradykinin desArg9), it activates the receptor in mice, B1 cells of T. With the entry of T-cells of the CNS and reduce clinical signs of inflammation decreased.

"We have a mechanism, which allows an inflammation, the immune system, neurologist and MDC Research Group Leader, explains Professor Zipp. "The question is whether we succeed in developing a new therapy for chronic inflammation in the central nervous system such as MS, in the future."