Transplantation of the ovary: the first child is born after a new technique

A new technique for transmission of the ovaries of women that their fertility after cancer treatment has been explained, the 25 annual conference of the European Society of Human Reproduction and Embryology today (Monday 29 June). Dr. Piver Pascal, Director of IVF, the Hospital of the University of Limoges, Limoges, France, described a new, close to the ovarian graft method, excellent results in women whose ovaries have been frozen because the therapy of cancer. He said that his team, the technique works Ovarialfunktion to fast food and a patient of his clinic had a baby and another was pregnant.

"On 22 June, a baby girl was born to a mother who, since the menopause for two years on the treatment of anemia of sickle cell. After transplantation of its own tissues ovulating ovaries, she began in four months pregnant and was, of course, six months after transplantation. mother and baby are doing well, "he says.

Dr. Piver and Members of Parliament, to meet one of the biggest problems of ovarian transplantation: the low response to stimulation, lack of vascularization of the transplanted tissue.

"For a pregnant woman, the ovaries of the need for hormones, for the release of eggs per month," he said. "If the blood of the ovary is not enough, they will be the same if the transplantation is as if it was successful. "

To resolve this problem on a two-stage procedure of first grafting small pieces of frozen ovarian tissue in ovarian and peritoneal areas three days before transplantation. The first registry to support the growth of blood vessels and opens the way for ovarian fully operational in less time as possible, if all the tissues were for transplant at the same time.

The researchers have so far is the technique of two patients being treated for cancer and had her ovaries frozen. In addition to the first patients treated cell anemia, the second patient was treated was to periarteritis nodosa, a medium-sized artery inflammation, swelling and damage to immune cells attack states.

"She was suffering from menopause and eight years before the transplant," said Dr. Piver. "But after the transplant, half of the ovary frozen, yet spontaneous ovulation in four months. Trompes your right has been destroyed by the extraction of the ovary, and ovarian function and therefore the chances of pregnancy are limited in time. Therefore, we decided for the greater number of eggs we have, and the implementation of a procedure for in vitro fertilization, for these patients.

"Six months after the operation, we have two blastocysts. A total of 22 oocytes were recovered and produced 16 embryos, which produced seven blastocyst. Unfortunately, for the first time of these patients developed an ectopic pregnancy, but it is pregnant again. "

The technique was by Dr. Piver and his team, he told the conference. "For the first time that pregnancy has received, after ten years of ovarian cryopreservation and transplantation. We believe this is a breakthrough for ovarian grafting methods used until now, partly because we are in the situation, for a large number of ova. We hope you make more young patients who have recovered from cancer, their health and be pregnant with their own children, "he said.