Some suffer Atopic vulnerable to virus and other

Since the World Health Organization of smallpox, officially announced the end of 1979 to eliminate - through the production of vaccination programs, the protection of immunity from orders "for most of the world - fear of fever, bubbles, sometimes deadly infectious diseases, pales. Indeed, more than three decades, the disease has been eradicated, vaccines against the routine is not nearly the majority of the population.

But if the September 11 tragedies fanned fear possible bioterrorist attack with a weapon of smallpox, the nation began his car quickly deliver vaccines. Unfortunately, the vaccine is intended, may be dangerous if half the country's population - including persons with atopic dermatitis (eczema or red, blurred, skin tingling), people who are positive, d 'organ recipients and patients on immunosuppressive treatment. E-New research published in the journal Allergy and Clinical Immunology, in this month sheds some light on the subsets of patients with eczema may be more at risk for complications of smallpox vaccination, and provides some clues why.

"The vaccine against the spread of some new concerns," said Lisa Beck, MD, associate professor of dermatology and medicine at the University of Rochester Medical Center, and study lead author. "Historical records show that patients at increased risk of eczema for the development of a serious infection of the virus active immunization - a cousin of the smallpox virus - which is in smallpox vaccines. Worse, since the reduction of these vaccines, some thirty years, the appearance of eczema has doubled every two years. "

Beck said he believes that 20 per cent of children now suffer from eczema.

"This infection can even as much as 20% of cases," she added. "More shocking, not only eczema naturally immunized patients, but also in eczema patients who have simply come into contact with other people recently vaccinated.

In March 2007, a new U.S. Army soldier immunized (in some armed personnel and health workers to obtain vaccines against smallpox), had delayed his temporary appointment in their country of origin and expected return, with his family in Indiana. When he accidentally infected his 2 year old son (has eczema), the boy was seriously ill, so that the titles of national recovery and recognition for the risks of smallpox vaccine.Just last week, Beck and his colleagues France publishes the results of the multi-center study in order to raise the profile of eczema, most patients are susceptible to infection of the skin. The study, commissioned by the National Institute of Allergy and Infectious Diseases, drew nearly 900 volunteers in seven research sites. Participants answered questions about their eczema, they would be experienced eczema Herpeticatum (or EH, more and more virus infection of the skin, only for patients and eczema by the herpes simplex virus) or bacterial skin infections, and even though she had asthma or food allergies. Awareness of their potential for other common allergens were analyzed, as the level of immune cells (immune system cells and mediators).

"We, the participants into three groups - healthy controls, contact dermatitis EH patients had at some point, eczema and disease, who have never EH," said Beck. "Our suspicion is that the medium group was vulnerable to many serious infections of the skin. We wanted to first confirm that an image can help us in the future, simply the most vulnerable among this group of patients. "

Truncated quickly the differences between the two groups of eczema patients. Those who have a history of EH not only as the eczema worse without EH, but was diagnosed as young, usually before the age of 5 years. They were also more vulnerable to allergic diseases like asthma and allergies, more sensitive to common allergens (of life throughout the years on insider trading houses, and dust mites, cockroaches and Dander PET) and were more than two and a half times longer treated bacterial infections of Staphylococcus aureus.

"The blood of this group EH few clues," said Beck. "It has been suggested that production of the same hypersensitive immune response, we are usually only in people with severe allergies."

This reaction is abnormal by the wrong type of immune system cells - a type with 2 T-Cell.

"These too excited to type 2 cells using Rush to put into practice what extreme measures, inflammation," said Beck. "Unfortunately, it is mainly T cells inhibit the production of antimicrobial proteins and prevent the skin is able, as a barrier, which the body's ability to defend the common pathogens, including viruses and bacteria."

Lessons learned from this research may be the best doctors know that patients with the next control after the vaccination, "said Beck.

"In a biological attack, we may be forced to vaccinate everyone within a certain radius, irrespective of any personal risk," she says.

Beck adds that this study, like many others, not for long assumed that human skin is a bit more of a flexible closure.

"We are beginning to recognize that the skin is much more an inert barrier," she says. "It seems to play an important role in jumpstarting the immune response. If you like the idea, it is easy to see how" the cracks in the armor "to a chronic disease of the skin such as eczema could help explain why some people more than others defenseless when it comes to the defense of some viruses. "