Vaccine can head genital cancers in women

A series of shots can Knock Out genital lesions among women with a dangerous strain of human papillomavirus, or HPV, a new study finds infected. Although the experimental vaccine was not effective in all tested showed most women seem to have many advantages, and develops long-lasting immunity against that strain of HPV and precancerous growths can spawn.

Two others were Gardasil and Cervarix vaccine approved for HPV infection in girls and young women who had not been prevented by the virus. The new vaccine is different to successfully treat active infection with HPV, which report the development of precancerous tumors, researchers at the 5th Triggered November New England Journal of Medicine did.

"It is a wonderful demonstration that these lesions disappear in May with vaccination," said Olivera Finnof cancer immunologist at the University of Pittsburgh School of Medicine. At best, they will offer shots, long lasting protection, but only tested on a large scale and prolonged follow-up will see that, "says Finn.

The researchers recruited 20 women who had lesions affecting the external tissues, such as genital. Tissue abnormalities caused by HPV-16, said that the most common cancer-causing virus strain, pain, itching and burning, study co-author Gemma Kenter, a gynecologist who worked on the then study at the University of Leiden in the Netherlands. Although lesions with laser treatment or surgery are removed, they often return, says Kent, now VU University Amsterdam.

All subjects received the new vaccine in a series of three or four injections that synthetic versions of two calls HPV proteins E6 and E7 contain. The vaccine is administered to the immune system to produce T cells - a type of white blood cells - to target any cell, these proteins is.

Two years after vaccination of these intra-epithelial lesions of the vulva has disappeared in nine women and showed a partial improvement in four others. Another participant seemed to enjoy, but he died of a heart attack before the process has been completed.

Six women did not improve. Although it remains unclear why six women did not benefit, "says Kenter, all had major injuries, and most were in the fight against precancerous growths of 10 years or more.

The new vaccine mobilization of T cells, immune agents, which says a root virus, which may have already invaded a cell, Finn. Viruses survive by integrating its DNA into the genome of a cell. The consistent genetic changes causing HPV infected cells, viral proteins that help produce the divergent growth of a cell.

However, cells of proteins E6 and E7 to the attention of T cells migrating. The immune response in slope of interferon-gamma-garde, a cellular signaling molecule. It serves as a fire alarm, immuno-pull troops kill cells infected by HPV.

HPV is very common, causing many women to be infected without symptoms. The new vaccine mimics the way most women clear HPV infections never develop lesions or cancer.

Among women, the benefits of the vaccine in the new study, the agency is not authorized infected cells, the vaccine Gardasil and Cervarix has been shown, "says Kent. Vaccines stimulate the production of antibodies that are looming on the virus are newcomers - which makes them very effective in girls and young women who have never been exposed to HPV. It was unclear efficacy of these vaccines are for women between May 20 and older who have a latent HPV infection, says Kenter.

For now, the objective of the new vaccine will be used in therapy - if it receives approval - in women with precancerous lesions in the genital area, "says Kenter. The Dutch team is already working on a larger study.